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In upstream bioprocessing, improvements have resulted in higher titer levels. Downstream processing needs to match these advances in a cost-efficient way

We call it downstream process intensification.

1. Column handling

Decrease packing time with up to 80%. Automate your columns.

Today it is possible to get packing right at first try. With automated column packing you can save both time and labor costs, compared with pack-in-place columns. Verified and automated packing methods help you achieve packing success independent of previous experience.

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Drop 9 out of 11 common preparation steps.
Choose prepacked columns.

Prepacked, prevalidated, and prequalified columns enable fast preparation times. Forget about CIP procedures, packing columns, and other preparation steps.

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“For AxiChrom, three people can pack the columns on three different machines and we will get virtually identical column efficiency and volume size. This gives us high production efficiency.” - Lead of Purification Department, high-tech biopharmaceutical company

2. Cleaning & validation

Skip manual handling steps.
Create closed systems.

You can connect the chromatography system, slurry tank, and column in a closed system. This way you minimize manual handling and reduce risk for cross contamination

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Set up your system ten times faster.
Select single-use flow path and prepacked columns.

You can quickly move to the next batch or change to a new campaign with single-use technology. Using prepacked columns and a chromatography system with a disposable flow path eliminates time spent on cleaning and cleaning validation.

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3. Buffer preparation

Decrease buffer volume with 60%.
Use in-line conditioning for your buffer preparation.

In-line conditioning minimizes buffer volumes and footprint. As opposed to in-line dilution, the technique also compensates for buffer variability in-line using combination of flow, pH and conductivity feedback controls.

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4. Continuous processing

Maximize resin capacity.
Implement continuous chromatography.

Periodic counter-current chromatography (PCC) is a multi-step continuous approach. It maximizes the use of chromatography resin capacity and minimizes process time.

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Remove hold up steps.
Use straight-through processing.

Straight-through processing (STP) connects two or more chromatography steps in series. With a minimal need of hold-up tanks and intermediate conditioning steps, you get a smaller footprint and an increased throughput.

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5. Automation

Improve operational efficiency.
Increase automation.

Data connectivity and a comprehensive automation solution can provide alignment across all facility functions. The result is an improved operational efficiency.

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Process intensification benefits

Great degree of flexibility

Today’s biomanufacturing is evolving towards multi-product facilities. With several processes running simultaneously, one size will not fit all. Therefore flexibility is a key to success.

Solutions for increased flexibility: single-use technologies, and scalable chromatography column platforms

Small footprint

As floor space is costly and not always available, every square meter must count. Achieving the same results with equipment with a smaller footprint can make more of your available space.

Solutions for reducing footprint: in-line conditioning, continuous chromatography, straight-through processing, single-use technologies, and modern chromatography resins

Improved process integration

As we are leaving the blockbuster era, the number of switches between batches and products are growing. By increasing turnaround you can achieve improved cost efficiency.

Solutions for improved unit integration: automated column packing, automation, straight-through processing and in-line conditioning

Less downtime and hold up steps

Speed to market is crucial. More uptime and less hold ups will help you get there. A larger number of batches can be produced, faster, and at a lower cost.

Solutions for less downtime and hold ups: straight-through processing, single-use technologies, automated column packing, and continuous chromatography